![]() Participants with index finger longer than ring finger were significantly less likely to have prostate cancer and the authors concluded that high digit ratio may confer a protective effect against the disease. Participants matched hand patterns with one of three drawings supplied by the researchers: index finger shorter than ring finger (low digit ratio) index finger equal to ring finger or index finger longer than ring finger (high digit ratio). 14, the researchers in the United Kingdom adopted a questionnaire format in order to secure the largest possible sample size (over 1500 prostate cancer patients and over 3000 controls). 15 Unlike the precise measurements of digits with high repeatability obtained by Choi et al. Of potential interest to the readers of the Asian Journal of Andrology is a 2011 report linking risk of prostate cancer to digit ratio. Though the authors report that Asian men have slightly shorter penises compared to other groups, and that the ethnic Han have the highest reported male digit ratios, they were not able to address the extent to which their digit ratio–penile length correlation may be specific to the particular ethnic composition of their study sample. However, given the increasingly long list of physical, medical and behavioral conditions related to digit ratio, this may have been an impossible task. 4, 9 The researchers also suggest that the subject pool was absent of patients whose medical conditions were known to be correlated with digit ratio. also argue that the homogeneous subject pool (Korean) reduced potential confounding variability since race and ethnicity are known to influence digit ratio. ![]() ![]() They counter criticisms that the longer penile lengths reflect testosterone's analgesic properties, because patients were anesthetized. In their discussion, the authors make their case for the predictive ability of digit ratio on adult stretched penile length. 14 concluded that higher prenatal androgen exposure is responsible for both the lower digit ratio and the longer penile length. Digit ratio was strongly (negatively) correlated with stretched penile length ( P=0.024). Flaccid and stretched penile lengths were measured in anesthetized patients with a rigid ruler, by a second researcher blind to the digit measurements. The researchers measured right hand digits directly with calipers, averaging repeated measures to calculate digit ratio. 14 The authors, Choi et al., provide convincing support for a relationship between digit ratio and penile length. 12 These criticisms, however, reflect increased focus on potential mechanisms (including a discussion of genetic contributions) underlying the development of the digit ratio trait, which remain to be elucidated.Īmidst a flurry of 2D:4D publications, mostly indicative of positive findings, 13 these criticisms were brought to light in a recent Asian Journal of Andrology report. However, it was neither the HOX nor the androgen receptor genes but an entirely different gene ( LIN28B) that was related to digit ratio in a recent study. 11 Similarly, much attention has been placed on the role of HOX A and D genes, since these are active early in the development of both limbs and gonads and could account for the relationship between hormone activity and digit ratio. An earlier report associating digit ratio and number of CAG repeats in the androgen receptor 10 recently failed to replicate. Still, the use of digit ratio as an indicator of androgen activity is not without criticism. 5 Over the past decade, the correlation of digit ratio with sexual behavior and other aspects of reproductive biology has been well documented 6, 7, 8, 9 and there is a growing list of traits with links to digit ratio, although the associations are less well established. 4 Perhaps the popular appeal is the relative simplicity of the measure, and the fact that researchers interested in any number of behavioral or physiological traits correlated with hormone activity have adopted digit ratio as a convenient biomarker for prenatal androgen exposure. ![]() 2, 3 Ratios are determined early in development and remain relatively stable thereafter. Digit ratio, most commonly the ratio of the index to ring fingers in humans, is sexually dimorphic (males have lower values than females) with greater differences on their right hand. Now advertized in at least one locale as the ‘sexy ratio' with the caption, ‘Your hands give away your hotness' ( !5794008 accessed ), an online summary of a recent study linking facial attractiveness to the ratio of the index and ring fingers 1 indicates that digit ratio (2D:4D) research has reached mainstream culture. ![]()
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